Resumen

Background: Cholinesterase is one of many important enzymes needed for the proper functioning of the nervous system. Objectives: Investigation of possible sources of interindividual variations in red blood cell cholinesterase (AChE) activity. Methods: A cross-sectional study of AChE activity and various physiologic and clinical variables was performed in a cohort of 306 male hazardous materials workers Simple correlations between AChE activity and various parameters to look for possible associations were carried out. Results: Simple correlation analysis demonstrated negative associations with ALT (r = 0.224, p < 0.001) and alkaline phosphatase activity (r = 0.128, p < 0.05) and positive associations with serum creatinine (r = 0.216, p < 0.001) and morbidity scores (r = 0.123, p < 0.05). Using multivariate regression, we found significant associations remained for serum creatinine and ALT, both p < 0.005. The most consistent association was for ALT. The subjects with the highest 10% and lowest 10% of AChE levels had significantly different ALT activities (30 ± 16 versus 53 ± 32, p<0.005). Finally, the 9 subjects with the absolute lowest ALT values had significantly higher AChE (24.6 ± 3.1) than the 8 subjects with the highest ALT values (20.2 ± 2.7) (p < 0.01). Conclusion: We found that liver dysfunction as measured by ALT was associated with depressed AChE. Further studies will be needed to investigate whether liver dysfunction renders one more susceptible to the effects of cholinesterase-inhibitors.

Palabras clave: Red blood cell cholinesterase transaminases liver function cholinesterase inhibitors humans.

2012-04-16   |   1,333 visitas   |   Evalua este artículo 0 valoraciones

Vol. 14 Núm.2. Abril-Junio 2011 Pags. Arch Inst Neurol 2011; 14(2)